Health News - Zetia + statin greatly decreases LDL cholesterol
Statins reduce the amount of cholesterol the liver makes, and ezetimibe (Zetia) prevents the intestine from absorbing cholesterol, used together these drugs lower LDL (”bad”) cholesterol much more than either drug alone. In a U.K. study reported in Current Medical Research and opinion, 148 patients received ezetimibe plus atorvastatin (Lipitor) or atorvastatin alone.
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After six weeks, the LDL of patients on double therapy dropped more than 50 percent–14 percent more than those on statin monotherapy. Patients on double therapy were also 12 times more likely to reach their LDL goals. A U.S. study of 469 high-risk patients reported in the American Journal of Cardiology had similar findings. At six weeks, 79.6 percent of those taking rosuvastatin (Crestor) plus ezetimibe, versus only 35 percent of those taking rosuvastatin alone, achieved the optimal LDL cholesterol goal of less than 70 mg/dl.
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